sars cov 2 pl pro (MedChemExpress)
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MedChemExpress
sars cov 2 pl pro
Sars Cov 2 Pl Pro, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sars+cov+2+pl+pro/SARS-CoV-2+PLpro/pmc12529399-134-27-30
Average 94 stars, based on 3 article reviews
Sars Cov 2 Pl Pro, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sars+cov+2+pl+pro/SARS-CoV-2+PLpro/pmc12529399-134-27-30
Average 94 stars, based on 3 article reviews
sars cov 2 pl pro - by Bioz Stars,
2026-11
94/100 stars
Images
1) Product Images from "SARS-CoV‑2 Papain-Like Protease Inhibitors Based on Naphthalen-1-ylethanamine and Halogenated Benzene Moieties"
Article Title: SARS-CoV‑2 Papain-Like Protease Inhibitors Based on Naphthalen-1-ylethanamine and Halogenated Benzene Moieties
Journal: ACS Omega
doi: 10.1021/acsomega.5c05856
Figure Legend Snippet: Docking simulation of GRL-0048 ( 2 ) (orange) or KTS146 ( 8 ) (yellow) and SARS-CoV-2 PL pro (PDB: 7CJM ). The blue area signifies the newly identified region in the binding pocket of SARS-CoV-2 PL pro .
Techniques Used: Binding Assay
Figure Legend Snippet: Structures of compounds ( 9a – y ), which target the hydrophilic amino acids of SARS-CoV-2 PL pro , with halogen substituents strategically positioned.
Techniques Used:
Figure Legend Snippet: (left) 2D ligand interactions of compound 9c with SARS-CoV-2 PL pro (PDB: 7CJM ) by MOE. (right) Docking simulation of compound 9c (orange) with SARS-CoV-2 PL pro (PDB: 7CJM ). The docking protocol is based on a rigid receptor.
Techniques Used:
Figure Legend Snippet: (left) 2D ligand interactions of compound 9m with SARS-CoV-2 PL pro (PDB: 7CJM ) by MOE. Docking simulation of compound 9m (orange) with SARS-CoV-2 PL pro (PDB: 7CJM ).
Techniques Used:
Figure Legend Snippet: (left) 2D ligand interactions of compound 9r with SARS-CoV-2 PL pro (PDB: 7CJM ) by MOE. Docking simulation of compound 9r (orange) with SARS-CoV-2 PL pro (PDB: 7CJM ).
Techniques Used:
Figure Legend Snippet: (left) 2D ligand interactions of compound 9v with SARS-CoV-2 PL pro (PDB: 7CJM ) by MOE. Docking simulation of compound 9v (orange) with SARS-CoV-2 PL pro (PDB: 7CJM ).
Techniques Used:
Related Articles
Drug discovery:Article Title: Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor Article Snippet: .. Using the previously optimized FRET assay condition, we performed a high-throughput screening of Article Title: Drug repurposing screening identified tropifexor as a SARS-CoV-2 papain-like protease inhibitor Article Snippet: .. Using the previously optimized FRET assay condition, we performed a high-throughput screening of Fluorescence:Article Title: SARS-CoV‑2 Papain-Like Protease Inhibitors Based on Naphthalen-1-ylethanamine and Halogenated Benzene Moieties Article Snippet: .. Briefly, the change in fluorescence intensity based on the cleavage of the fluorogenic substrate Z-Arg-Leu-Arg-Gly-Gly-4-methylcoumaryl-7-amide (AMC) (Sigma-Aldrich) caused by the SARS-CoV-1 PL pro (LifeSensors, Malvern, PA) or |